In this recent article the authors from the Münster group highlight the urgent need to further develop the clinical genetic diagnostic workup of infertile males beyond the unchanged practice of the last 20 years, which comprises solely screening for chromosomal aberrations and Y-chromosomal AZF deletions. Thus, in a pilot study, they started to analyse a small gene panel consisting of TEX11, NR5A1 and DMRT1 in azoospermic men and found likely pathogenic mutations as a cause of azoospermia in 5% of patients. Comparable to other diseases, this clearly illustrates the power of gene-panel sequencing also in infertile males.
Our mission is to identify and characterize the genetic causes of male infertility, allowing for improved diagnostics, development of novel treatments and enhanced patient care
Recent News & Publications
- – The European Testis Workshop, Obidos Portugal, May 23-27: http://www.etw2018.org/
- – The European Society of Human Genetics Conference (ESHG), Milan Italy, June 16–19: https://2018.eshg.org/
- – The Society for the Study of reproduction (SSR), New Orleans USA, July 10-13: http://www.ssr.org/18Meeting
- – The European Congress of Andrology (ECA) in Budapest Hungary, October 11-13. http://www.eca2018.com/
- – The American Society of Human Genetics, San Diego USA, October 16-20: http://www.ashg.org/2018meeting/