Utah University

Member Details

Ki Aston, PhD, HCLD
Associate Professor of Surgery (Urology)
University of Utah School of Medicine
Andrology and IVF Laboratories
675 Arapeen Dr, Suite 201
Salt Lake City, UT 84108

Telephone: 801-587-3706
Email: kiaston@utah.edu
University URL: https://healthcare.utah.edu/fad/mddetail.php?physicianID=u0596435

Member Description

Dr. Aston completed his Ph.D. at Utah State University, where he evaluated factors associated with somatic cell nuclear transfer efficiency and nuclear reprogramming. He was involved in bovine nuclear transfer and was part of the first group to successfully clone an equine species. Following his graduate training, Ki joined the Andrology and IVF team at the University of Utah as a Post Doctoral Fellow and later as a member of the faculty in the Division of Urology. His research team focuses on identifying genetic and epigenetic factors associated with male infertility. He is a lead investigator for the NIH-funded Genetics of Male Infertility Initiative (GEMINI), which will generate exome sequences on 1000 men with idiopathic nonobstructive azoospermia. In addition, his lab is involved in several projects to define the normal sperm epigenome, to identify factors that alter sperm epigenetic profiles and to characterize the impacts of altered sperm epigenetics on offspring phenotype.

Publications

Jenkins TG, Aston KI, Pflueger C, Cairns BR, Carrell DT. Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet. 2014 Jul;10(7):e1004458.

Lopes AM, Aston KI, Thompson E, Carvalho F, Goncalves J, Huang N, Matthiesen R, Noordam MJ, Quintela I, Ramu A, Seabra C, Wilfert AB, Dai J, Downie JM, Fernandes S, Guo X, Sha J, Amorim A, Barros A, Carracedo A, Hu Z, Hurles ME, Moskovtsev S, Ober C, Paduch DA, Schiffman JD, Schlegel PN, Sousa M, Carrell DT, Conrad DF. Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1. PLoS Genet. 2013 Mar;9(3):e1003349.

Funding

NIH R01HD078641 genomics of spermatogenic impairment

NIH R21ES023330 Transgenerational tobacco smoke induced changes in the male germline in the mouse