Radboud Medical Center
Geert Grooteplein Zuid 10
Telephone: +31 24 361 3147
- Godfried van der Heijen – Researcher
Improvement of and setting standards for clinical phenotyping, building structures to collect well-phenotyped patient groups, e.g. based on testicular histology.
Human spermatogenesis is understudied. This stems among others from a scarcity of testis material carrying a defined genetic mutation. The application of WES on infertile patients cohorts in combination with access to testis material of these patients finally allows systematic probing of human spermatogenesis. In my research I am chartering the consequences of such newly identified mutations on germline homeostasis and transcriptional dynamics.
van de Werken C, van der Heijden GW, Eleveld C, et al (2014) Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications. Nat Commun 5:5868.
Castañeda J, Genzor P, Heijden GW, et al (2014) Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice. EMBO J 33:1999–2019.
van der Heijden GW, Castañeda J, Bortvin A (2010) Bodies of evidence-compartmentalization of the piRNA pathway in mouse fetal prospermatogonia. Curr Opin Cell Biol 22:752–757.
Aravin AA, van der Heijden GW, Castañeda J, et al (2009) Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice. PLoS Genet 5:e1000764.
van der Heijden GW, Derijck AAHA, Pósfai E, et al (2007) Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation. Nat Genet 39:251–258.