Robert Ian McLachlan
Director of Clinical Research
Hudson Institute of Medical Research
27-31 Wright Street, Clayton, Aust 3168
Telephone: (Secretary) 61-3-95943553
Email: rob.mclachlan@hudson.org.au
Hudson Institute of Medical Research
- Robert Ian McLachlan
Improvement of and setting standards for clinical phenotyping, building structures to collect well-phenotyped patient groups, e.g. based on testicular histology.
Clinical and research interests include male reproductive endocrinology & the evaluation & management of male infertility, and androgen physiology and studies on their use and abuse. He has particular interests in the genetics of male infertility, the optimal use of assisted reproduction and the follow up on ART offspring health.
Kimmins S, Anderson RA, Barratt CLR et al (2023) Frequency, morbidity and equity – the case for increased research on male fertility. Nat Rev Urol.
Handelsman DJ, Grossmann M, Yeap BB et al (2023) Long-Term Outcomes of Testosterone Treatment in Men: A T4DM Post-Randomisation Observational Follow-Up Study. J Clin Endocrinol Metab.
Catford SR, Halliday J, Lewis S et al (2022) The metabolic health of young men conceived using intracytoplasmic sperm injection. Hum Reprod. 37(12):2908-2920.
Catford SR, Halliday J, Lewis S et al (2022) Reproductive function in men conceived with in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril. 117(4):727-737.
Björndahl L, Barratt CLR, Mortimer D et al (2022) Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology. Hum Reprod. 37(11):2497-2502.
Nagirnaja L, Lopes AM, Charng WL et al (2022) Diverse monogenic subforms of human spermatogenic failure. Nat Commun. 13(1):7953
O’Donnell L, Rebourcet D, Dagley LF et al (2021) Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men. FASEB J. 35(3):e21397.
Catford SR, Lewis S, Halliday J, et al (2020) Health and fertility of ICSI-conceived young men: study protocol. Hum Reprod Open.
Novakovic B, Lewis S, Halliday J, et al (2019) Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood. Nat Commun 10:3922.
Catford SR, McLachlan RI, O’Bryan MK, Halliday JL (2017) Long-term follow-up of intra-cytoplasmic sperm injection-conceived offspring compared with in vitro fertilization-conceived offspring: a systematic review of health outcomes beyond the neonatal period. Andrology 5:610–621.
Catford SR, McLachlan RI, O’Bryan MK, Halliday JL (2018) Long-term follow-up of ICSI-conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period. Andrology 6:635–653.
Oud MS, Ramos L, O’Bryan MK, et al (2017) Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia. Hum Mutat 38:1592–1605.
Catford SR, O’Bryan MK, McLachlan RI, et al (2019) Germ cell arrest associated with aSETX mutation in ataxia oculomotor apraxia type 2. Reprod Biomed Online 38:961–965.
2017-2021 Australian NH&MRC Project Grant #GNT1120356 (CIB)
The genetic causes of male infertility
2020-2024 Australian Medical Research Future Fun [MRFF] Emerging Priorities and Consumer Driven Research initiative EPCD000007
Men and Infertility over the life course (MAIL) CIs G Chambers, R McLachlan, J Halliday, M O’Bryan S. Von Saldern $4,600,000
2023-2027 Australian NHMRC Clinical Trials and Cohort Studies GNT2023952 (CID) The use of scrotal cooling to improve semen quality and pregnancy rates within infertile men A$1,165,000