Member Details

Kristian Almstrup
Associate Professor, Senior Scientist
Copenhagen University Hospital – Rigshospitalet
9 Blegdamsvej, Section GR-5064
DK-2100 Copenhagen


Team Members
  • Sofia B. Winge – Senior Scientist
  • Nina Mørup – Postdoc
  • Gülizar Saritas – PhD Student
  • Maria Lykkegaard Nicolaisen – PhD Student
  • Ailsa Maria Main – PhD Student
  • Ewa Rajpert-De Meyts – Consultant


Improvement of and setting standards for clinical phenotyping, building structures to collect well-phenotyped patient groups, e.g. based on testicular histology.

Member Description

Kristian Almstrup and his group focus on studies connecting genetic and epigenetic variation (including small RNAs) to reproductive endpoints, testicular gene expression and functional studies of sperm cells.


Almstrup K (2023) Small RNAs in andrology: Small messengers with large perspectives. Andrology 11(4):625-7.

Murat F, Mbengue N, Winge SB et al (2023) The molecular evolution of spermatogenesis across mammals. Nature 613:308–16.

Almstrup K, Lobo J, Mørup N, et al (2020) Defective piRNA Processing and Azoospermia. New England Journal of Medicine 386(17):1676.

Nagirnaja L, Lopes AM, Charng WL (2022) Diverse monogenic subforms of human spermatogenic failure. Nature Communications;13(1):7953.

Nagirnaja L, Mørup N, Nielsen JE et al (2021) Variant PNLDC1, Defective piRNA Processing and Azoospermia. New England Journal of Medicine 385(8):707-19.

Winge SB, Soraggi S, Schierup MH, et al (2020) Integration and reanalysis of transcriptomics and methylomics data derived from blood and testis tissue of men with 47,XXY Klinefelter syndrome indicates the primary involvement of Sertoli cells in the testicular pathogenesis. Am J Med Genet Part C Semin Med Genet 184:239–255.

Almstrup K, Lobo J, Mørup N, et al (2020) Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours. Nat Rev Urol 17:201–213.

Soraggi S, Riera M, Rajpert-De Meyts E, et al (2020) Evaluating genetic causes of azoospermia: What can we learn from a complex cellular structure and single-cell transcriptomics of the human testis? Hum Genet.

Kumar K, Trzybulska D, Tsatsanis C, et al (2019) Identification of circulating small non-coding RNAs in relation to male subfertility and reproductive hormones. Mol Cell Endocrinol 492:110443.

Mørup N, Busch AS, Bang AK, et al (2017) Polymorphisms in JMJD1C are associated with pubertal onset in boys and reproductive function in men. Sci Rep 7:17242.


Novo Nordisk Foundation