Copenhagen University Hospital
- Nina Mørup – Phd Student
- Sofia B. Winge – Postdoc
- Ewa Rajpert-De Meyts – Consultant
WORKING GROUP: CLINICS
Improvement of and setting standards for clinical phenotyping, building structures to collect well-phenotyped patient groups, e.g. based on testicular histology.
Kristian Almstrup and his group focus on studies connecting genetic and epigenetic variation (including small RNAs) to reproductive endpoints, testicular gene expression and functional studies of sperm cells.
Winge SB, Soraggi S, Schierup MH, et al (2020) Integration and reanalysis of transcriptomics and methylomics data derived from blood and testis tissue of men with 47,XXY Klinefelter syndrome indicates the primary involvement of Sertoli cells in the testicular pathogenesis. Am J Med Genet Part C Semin Med Genet 184:239–255.
Almstrup K, Lobo J, Mørup N, et al (2020) Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours. Nat Rev Urol 17:201–213.
Soraggi S, Riera M, Rajpert-De Meyts E, et al (2020) Evaluating genetic causes of azoospermia: What can we learn from a complex cellular structure and single-cell transcriptomics of the human testis? Hum Genet.
Kumar K, Trzybulska D, Tsatsanis C, et al (2019) Identification of circulating small non-coding RNAs in relation to male subfertility and reproductive hormones. Mol Cell Endocrinol 492:110443.
Mørup N, Busch AS, Bang AK, et al (2017) Polymorphisms in JMJD1C are associated with pubertal onset in boys and reproductive function in men. Sci Rep 7:17242.