Institute of Genetic Medicine
International Centre for Life
Newcastle upon Tyne
Telephone: 0191 241 8611
Fax: 0191 241 8666
- Bilal Alobaidi – Senior research technician
- David Elliott – Geneticist, RNA biology expert
- Francesco Kumara Mastrorosa – PhD student
- Giles Holt – Postdoctoral fellow
- Hadeel Ismail – Research technician
- Hannah Smith – PhD student
- Harsh Sheth – Senior postdoctoral fellow
- Jackie Greenwood – Research nurse
- Kevin McEleny – Consultant urological surgeon and andrologist
- Miguel Xavier – Postdoctoral fellow
- Kathleen D’Hauwers – Urologist
- Kathrin Fleischer – Gynaecologist, head Department of Reproductive Medicine
- Liliana Ramos – Clinical embryologist
- Lisenka Vissers – Assistant professor translational genomics
- Godfried vander Heijden – Clinical embryologist
- Manon Oud – PhD student
- Petra de Vries – Senior research technician
The genomics and bioinformatics working group will focus on setting standards for performing, analyzing and sharing data from genomics studies.
Prof. Veltman leads a multidisciplinary research group with expertise in genome technology, molecular biology and bioinformatics. The group is particularly focused on studying the role of de novo mutations and structural variation in severe forms of male infertility, using patient-parent trio based exome and genome sequencing, high-throughput bioinformatics analyses and statistical models. Most recently, the group has developed a low-cost, high-throughput molecular inversion probe (MIP) based sequencing assay to screen for point mutations and copy number variation in 100 candidate genes associated with male infertility (Oud et al, Human Mutation 2017). In addition, we have started RNA sequencing pilot studies in germ cell populations from FACS sorted testis biopsies of fertile and infertile men. We aim to identify genes and biological mechanisms involved in male (in)fertility and consecutively develop genetic tests for implementation in routine diagnostics. In addition, we are studying the impact of parental age and the use of assisted reproductive technologies on the health of the offspring. Prof. Veltman recently moved from Radboudumc in Nijmegen, The Netherlands, to Newcastle University, Newcastle-upon-Tyne, United Kingdom. He holds a joint position at both Universities. The male infertility studies are done in close collaboration with fertility experts from both Universities/University Hospital Trusts.
Oud MS, Volozonoka L, Smits RM, Vissers LELM, Ramos L, Veltman JA. A systematic review and standardized clinical validity assessment of male infertility genes. Hum Reprod. 2019;38(11):1592-1605.
Oud MS, Ramos L, O’Bryan MK, Mclachlan RI, Okutman O, Viville S, de Vries PF, Smeets DF, Lugtenberg D, Hehir-Kwa JY, Gilissen C, van de Vorst M, Vissers LE, Hoischen A, Meijerink AM, Fleischer K, Veltman JA, Noordam MJ. Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia. Human Mutation 2017. 38(11): 1592-1605.
Personal research grant Prof. Veltman (VICI), Netherlands Organization for Scientific Research: Causes and consequences of de novo mutations in intellectual disability and male infertility (2016-2020).
Wellcome Trust Senior Investigator Award: De novo mutations in male infertility (2018-2023)